BOC-D-FMK
作者：齊岳
發(fā)布時(shí)間：2023-08-28
09:04:48
點(diǎn)擊數(shù)：
產(chǎn)品名稱：BOC-D-FMK
產(chǎn)品描述：
| 產(chǎn)品描述 | Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM). |
| 體外活性 | Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation [1]. Boc-D-fmk (50 μM) prevents genistein-induced apoptosis of p815 cells. The release of mitochondrial apoptotic factors is inhibited by Boc-D-fmk [2]. |
| 體內(nèi)活性 | Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after the endotoxin challenge [3]. Boc-D-FMK (single injection) results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle [4]. |
| 分子量 | 263.26 |
| 分子式 | C11H18FNO5 |
| CAS No. | 634911-80-1 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 125 mg/mL (474.82 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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