Friedelin
作者：齊岳
發(fā)布時(shí)間：2023-08-29
13:40:48
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Friedelin
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 燈心草科 > 燈心草屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 萜類 |
| 產(chǎn)品描述 | Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. |
| 靶點(diǎn)活性 | CYP2E1:22.54?μM (IC50), CYP3A4:Ki: 6.16?μM, CYP2E1:18.02?μM (IC50), CYP3A4:10.79?μM (IC50) |
| 體外活性 | In in vitro antioxidant study, the free radical scavenging effect of Friedelin on 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated. Friedelin showed very good scavenging effect on DPPH (IC50 21.1 mM), hydroxyl (IC50 19.8 mM), nitric oxide (IC50 22.1 mM) and superoxide (IC50 21.9 mM) radicals. Friedelin also showed strong suppressive effect on lipid peroxidation. In in vivo antioxidant study, CCl4 induced oxidative stress on rats produced significant increase in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) levels along with reduction in liver superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels. Pre-treatment of rats with Friedelin at 40 mg/kg for 7 days restored these levels to normality and showed liver protection, comparable to the standard, silymarin (25 mg/kg)[1] |
| 別名 | 軟木三萜酮, 無羈萜 |
| 分子量 | 426.72 |
| 分子式 | C30H50O |
| CAS No. | 559-74-0 |
存儲(chǔ)
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: Insoluble
DMSO: Insoluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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