δ-secretase inhibitor 11
作者：齊岳
發(fā)布時間：2023-08-29
13:40:47
點擊數(shù)：
產(chǎn)品名稱：δ-secretase inhibitor 11
產(chǎn)品描述：
| 產(chǎn)品描述 | δ-secretase inhibitor 11 isan inhibitor ofδ-secretase and can be used as a lead compound for translational development of AD treatment. |
| 體外活性 | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15?±?0.09?μM [1]. |
| 體內(nèi)活性 | It was found that oral administration of δ-secretase inhibitor 11(10?mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
| 分子量 | 220.232 |
| 分子式 | C10H12N4O2 |
| CAS No. | 842964-18-5 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 2.2 mg/mL (10 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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