Jaceosidin
作者：齊岳
發(fā)布時間：2023-08-30
09:00:42
點擊數(shù)：
產(chǎn)品名稱：Jaceosidin
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 菊科 > 蒿屬 |
| 結構類型 | 天然產(chǎn)物 > 類黃酮 |
| 產(chǎn)品描述 | Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin has immunosuppressive effect through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. The pharmacokinetics of Jaceosidin may be dramatically affected by polymorphic CYP1A2, UGT1A1, and UGT1A7 responsible for the metabolism of Jaceosidin or by the coadministration of relevant CYP1A2 or UGT inhibitors or inducers. |
| 分子量 | 330.29 |
| 分子式 | C17H14O7 |
| CAS No. | 18085-97-7 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 125 mg/mL (378.46 mM),Need ultrasonic
Ethanol: 7.14 mg/mL (21.62 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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