Tauroursodeoxycholate sodium
作者：齊岳
發(fā)布時間：2023-08-30
09:02:39
點擊數(shù)：
產(chǎn)品名稱：Tauroursodeoxycholate sodium
產(chǎn)品描述：
| 產(chǎn)品描述 | Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
| 體內(nèi)活性 | In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2] |
| 細胞實驗 | Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter. |
| 動物實驗 | Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection |
| 別名 | ?；切苊撗跄懰徕c, TUDC, Sodium tauroursodeoxycholate, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), 牛磺熊去氧膽酸鈉 |
| 分子量 | 521.69 |
| 分子式 | C26H44NNaO6S |
| CAS No. | 35807-85-3 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 10 mg/mL(19.2 mM)
DMSO: 93 mg/mL (178.3 mM)
H2O: 92 mg/mL (176.3 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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